#Flash: Intraosseous Vancomycin reduces periprosthetic joint
This study compared the frequency of PJI, adverse reactions, and complications associated with IV versus intraosseous (IO) vancomycin at 30-day, 90-day, and one-year follow-up. A retrospective study of 1,060 TKA patients was conducted. With a minimum of 30 days of follow-up, there were 572 patients in the IV group and 488 in the IO group. With a minimum 90-day follow-up, the incidence of PJI was 1.4% in the IV group and 0.22% in the IO group. This pilot study found that using IO vancomycin in combination with a first-generation cephalosporin reduced the incidence of infection in TKA patients. Specifically, IO vancomycin administration following tourniquet inflation is a safe and effective alternative.

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Source: https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.103B6.BJJ-2020-2401.R1?af=R