1 in 5 Diabetes Patients Hospitalized With COVID-19 Die in 2
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Although half of patients with diabetes hospitalized with COVID-19 will be discharged from hospital within a month of admission, a fifth will have died, suggest the latest results from the French CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study.

This is an update of the results from the previous report of the CORONADO study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalized for COVID-19.

The CORONADO initiative is a French nationwide multicenter study of patients with diabetes hospitalized for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. They mainly focused on hospital discharge and death within 28 days.

Results:
-- The study included 2796 participants: 63.7% men, mean age 69.7±13.2 years, median BMI (25th–75th percentile) 28.4 (25.0–32.4) kg/m2.

-- Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively.

-- Within 28 days, 1404 were discharged from hospital with a median duration of hospital stay of 9 (5–14) days, while 577 participants died.

-- In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge.

-- History of microvascular complications, anticoagulant routine therapy, dyspnea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge.

-- Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors.

Conclusively, in patients with diabetes hospitalized for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period.

Source: https://link.springer.com/article/10.1007/s00125-020-05351-w
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