14-days of ketone supplementation lowers glucose and improve
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Postprandial hyperglycemia increases systemic inflammation and is a risk factor for cardiovascular disease. A ketone monoester (KME) drink containing β-hydroxybutyrate (β-OHB) rapidly lowers plasma glucose, which may be a strategy protecting against postprandial hyperglycemia. Researchers hypothesized that KME would attenuate 2-hour postprandial glucose, lower systemic inflammation, and improve vascular function in adults with obesity.

In a randomized crossover design, 14 participants with obesity (age = 56±12 yrs; BMI = 32.8±7.7 kg/m 2) consumed KME (12 g β-OHB) or placebo 15-minutes prior to each meal for 14-days with all meals provided and matched between conditions. Postprandial glycemia was assessed by continuous glucose monitoring. Vascular function and inflammation were assessed before and after treatment periods.

Results:
-- Postprandial glucose was 8.0% lower in KME versus placebo and 24-hour average glucose reduced by 7.8%.

-- Brachial artery flow-mediated dilation increased from 6.2±1.5% to 8.9±3.3% in KME with no changes in placebo.

-- There were no changes in plasma cytokines; however, LPS-stimulated monocyte caspase-1 activation was lower following KME supplementation versus placebo.

-- The KME supplement was well tolerated by participants and adherence to the supplementation regimen was very high.

Conclusively, in adults with obesity, 14-days of pre-meal KME supplementation improves glucose control, enhances vascular function, and may reduce cellular inflammation. KME supplementation may be a viable, non-pharmacological approach to improving and protecting vascular health in people with heightened cardiometabolic risk.

Source: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa925/6052998?redirectedFrom=fulltext
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