3-D biopsies to better understand brain tumors
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Researchers obtained a highly accurate recreation of human glioblastoma's features using a novel 3-D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutic strategies.

With this new approach, authors show the alterations in tumor blood vessels, and that these vascular wall abnormalities do not hinder the entrance of lymphocytes T (potential defense against tumoral cells), which is relevant for the design and use of immunotherapies targeting malignant cells.

Moreover, the images allow the tumor to be differentiated into two areas, the tumor tissue properly speaking, and the stroma, which gives support to the tumor, in which there are different immunological microenvironments. "Immune cells like microglia and macrophages are seen in both areas, but they are shaped by different subpopulations. This local and populational differentiation could be an important factor that may help diagnosis and aid in the search for new therapeutic targets," says the coordinator of the work.

The work provides a set of resource images that will facilitate the understanding of the complexity of this tumor, showing some aspects to be considered when designing new therapeutic approaches.

Source: https://doi.org/10.1186/s40478-020-01115-0
Like
Comment
Share