39% Of People On Long-Term Antidepressants Have Depression R
A study revealed that people who come off their antidepressant medication are significantly more likely to relapse than those who stay on them. Researchers followed 500 depressed people in remission; who had previously been taking citalopram, sertraline, fluoxetine or mirtazapine for at least nine months – for a year. 240 patients in the group were taken off their medication after two months of taking a reduced dose as part of a tapering regime and then given a placebo pill, so they did not know they weren't taking the medication. The other 238 participants kept taking their antidepressants. Those who were phased off their medication had a 56% risk of becoming clinically depressed again. Patients who carried on with their prescription were 39% likely to relapse. It was concluded that long-term antidepressant use reduces the chance of suffering from depression.

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https://www.nejm.org/doi/full/10.1056/NEJMoa2106356
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