3D Liver Segmentation Helps Identify Fatty Liver On Cardiac
A 3D liver segmentation technique can be useful to quickly diagnose and measure fatty liver on cardiac CT exams, according to a research. The researchers sought to evaluate the reproducibility of a novel approach of three dimensional, 3D liver volume segmentation to identify fatty liver on non-contrast cardiac CT, and compare measures with previously validated 2D segmentation CT criteria for measurement of liver fat.

Liver fat measures generated by 2D segmentation on cardiac CT have been correlated with the gold standard of invasive liver biopsy and used in research studies. But the 2D method is inaccurate for diagnosing low-fat content and lacks stability with repeat measures", Dr. Suvasini Lakshmanan, an advanced cardiac imaging fellow and the presenter was quoted.

In a new study conducted by a group of researchers from the Lundquist Institute at Harbor-UCLA Medical Center in Torrance, California, U.S.A., both 3D and 2D segmentation in over a total of 100 patients receiving serial non-contrast cardiac CT examinations were included. Following which the fatty liver was diagnosed based on liver attenuation of less than 40 Hounsfield units. Both 2D and 3D liver segmentation was performed on the non-contrast cardiac CT images using software from Philips Healthcare, according to Dr. Lakshmanan.

Following which they found that the 3D method was stable and reproducible for measuring liver fat. Also, they found a kappa of 88% when 2D and 3D liver measurements both identified fatty liver, indicating excellent agreement. Dr. Suvasini Lakshmanan was quoted as, "The measure can serve as an imaging biomarker to understand mechanistic correlations between atherosclerosis, fatty liver, and cardiovascular disease risk."

She concluded by stating, "Nonetheless serial assessments of Non-alcoholic fatty liver disease (NAFLD) on cardiac CT will allow for future research to evaluate the effect of anti-inflammatory or anti-atherosclerotic therapies on cardiovascular disease and fatty liver."