3D 'mini-brains' grown from stem cells help understand rare
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Scientists have grown 3D 'mini-brains' from stem cells and used them to better understand how a rare congenital brain defect develops.

A new method could push research into developmental brain disorders an important step forward, researchers said.

Scientists at the University of Bonn in Germany converted skin cells from patients into induced pluripotent stem cells.

From these 'jack-of-all-trades' cells, they generated brain organoids - small 3D tissues which resemble the structure and organisation of the developing human brain.

Investigations into human brain development using human cells in the culture dish have so far been very limited: the cells in the dish grow flat, so they do not display any three-dimensional structure.

Model organisms are available as an alternative, such as mice. The human brain has, however, a much more complex structure. Developmental disorders of the human brain can thus only be resembled to a limited degree in the animal model....

http://www.dnaindia.com/health/report-3d-mini-brains-help-understand-rare-developmental-disorders-2382400
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