3D wide-field Multispectral Photoacoustic Imaging of human m
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The Breslow depth is an important parameter to determine the excision margin and prognosis of melanoma. A Study was conducted to evaluate the use of 3D wide-field multispectral photoacoustic imaging to non-invasively measure depth and outline the boundary of melanomas for optimal surgical margin selection.

6 melanoma patients were examined in vivo using the 3D multispectral photoacoustic imaging system. For five cases of melanomas (one in situ, three nodular, and one acral lentiginous type melanoma), the spectrally unmixed photoacoustic depths were calculated and compared against histopathological depths.

Results:
--Spectrally unmixed photoacoustic depths and histopathological depths match well within a mean absolute error of 0.36 mm.

--In particular, the measured minimum and maximum depths in the in situ and nodular type of melanoma were 0.6 and 9.1 mm, respectively.

--In the 3D photoacoustic image of one metastatic melanoma, feeding vessels were visualized in the melanoma, suggesting the neovascularization around the tumour.

In addition to the well measured depth and sizes of different melanomas, 3D multi-spectrum photoacoustic imagery also provides a view of the metastatic molanoma type. Accurate melanoma depth and limits details prior to the procedure will play a helpful role in the full melanoma excision during the surgery.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.16985?af=R
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