5-Fluorouracil in Dermatology: The Diverse Uses Beyond Malig
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
5-fluorouracil (5-FU) is widely used for treatment of malignant and premalignant skin cancers; however, its use in other common cutaneous conditions has been less widely reported.

Researchers investigated the off-label uses of 5-FU beyond malignant and premalignant skin disease.

They conducted a literature review searching multiple databases to evaluate the evidence for the off-label uses of 5-FU. The level of evidence was evaluated and selected accordingly listing the studies with the highest level of evidence first using the Oxford Centre of Evidence-Based Medicine 2011 guidance.

Authors found underlying evidence to support the use of 5-FU for a wide range of noncancerous cutaneous indications including scarring (keloid, hypertrophic), pigmentary disorders (vitiligo, idiopathic guttate hypomelanosis), cutaneous infections (viral warts, molluscum contagiosum), inflammatory dermatoses (Darier's disease, Hailey-Hailey disease and sarcoidosis), and cosmetic indications (photoaging, treatment of filler nodules and granulomas).

Conclusively, in selected patients, 5-FU can be as effective as more established treatments, with fewer side-effects.

Source: https://journals.lww.com/dermatologicsurgery/Abstract/2021/03000/5_Fluorouracil_in_Dermatology__The_Diverse_Uses.6.aspx
1 share
Like
Comment
Share