A Clinicobiochemical Evaluation Of Curcumin As Gel And As Bu
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To evaluate and compare the efficacy of topical curcumin gel and buccal mucoadhesive patches in the management of oral submucous fibrosis (OSMF) a study was conducted.

40 clinically diagnosed oral submucous fibrosis patients were randomly divided into two groups. Group A received curcumin gel and group B curcumin mucoadhesive patches, to be used twice daily for 8 weeks. The evaluation was done every 2 weeks. Serum lactate dehydrogenase (LDH) levels were measured before and after treatment and also in 20 healthy controls.

100 % reduction in burning sensation was observed in all 40 patients at the end of 4 weeks. Mouth opening improved by 5.45 ± 1.64 mm in group A and 5.9 ± 2.00 mm in group B. Pre-treatment lactate dehydrogenase was 359.72 ± 77.02 IU/L in oral submucous fibrosis patients which was significantly higher than healthy volunteers. In group A, lactate dehydrogenase values reduced from 341.85 ± 71 IU/L to 264.95 ± 65.09 IU/L, and in group B, from 377.6 ± 79.76 IU/L to 286.15 ± 72.95 IU/L after treatment.

Curcumin gel and mucoadhesive patches were effective in improving the mouth opening and reducing burning sensation in oral submucous fibrosis patients. They can, therefore, be considered as safe, non-invasive modalities for oral submucous fibrosis.

Source:https://www.oooojournal.net/article/S2212-4403(20)31422-X/fulltext?rss=yes
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