A Novel Stimulus to Improve Perimetric Sampling within the M
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Identifying glaucomatous damage to the macula has become important for diagnosing and managing patients with glaucoma. This study, presented an approach that provides better perimetric sampling for the macular region, by testing four locations, with a good structure-function agreement.

This Study was aimed to improve perimetric sampling within the macula by presenting a stimulus at four locations, with maintaining a good structure-function agreement.

Researchers tested one eye each of 30 patients. Patients were selected based on observed structural damage to the macula, whereas perimetric defect (using 24-2) did not reflect the locations and extent of this damage.

Researchers used en face images to visualize retinal nerve fiber bundle defects. To measure perimetric sensitivities, a blob stimulus (standard deviation of 0.25°) at the 10-2 locations was used. A perimetric defect for a location was defined as any value equal to or deeper than -4, -5, and -6 dB below the mean sensitivity for 37 age-similar controls (aged 47 to 78 years). An elongated sinusoidal stimulus for 20 patients at four locations within the macula was also presented , in which a perimetric defect as any value below the 2.5th percentile from controls was defined.

--The -4, -5, and -6 dB criteria identified perimetric defects in 14, 13, and 11 patients, respectively.

--When testing with the elongated stimulus, 18 patients were identified with perimetric defect. The perimetric defects were consistent with the structural damage.

Finally, the elongated stimulus demonstrated strong structure-function agreement with just four research locations compared to 68 for the blob stimulus. This shows that this new stimulation has therapeutic promise in the next generation of perimetry.

Source: https://journals.lww.com/optvissci/Fulltext/2021/04000/A_Novel_Stimulus_to_Improve_Perimetric_Sampling.10.aspx