A Unique Hairy Cell Leukemia Variant
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Hairy cell leukemia (HCL) is a rare mature B-cell lymphoid leukemia with an indolent course.It accounts for approximately 2% of all leukemias, has a male-to-female ratio of 4: 1,and a median age at diagnosis of 58 years.Clinically, patients typically present with pancytopenia, splenomegaly, and often absolute monocytopenia. Morphologically, HCL in peripheral blood is characterized by mature B cells with circumferential cytoplasmic projections resembling hairs.Histologically, HCL cells in bone marrow biopsies have abundant cytoplasm surrounding the nuclei, resembling a fried egg.A 65-year-old woman presented with easy bruising, left upper quadrant pain, decreased appetite, and weight loss....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939668/
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