A grave case of vomiting: GIT manifestations of hyperthyroid
The following case has been reported in the American Journal of Medicine.

A 60-year-old woman presented with intractable nausea and vomiting, which had progressively intensified over the past 2 weeks. Her past medical history was remarkable for mild thrombocytopenia and mildly elevated liver enzymes. Her vomiting was triggered by oral intake, nonbloody and nonbilious, and associated with nonresolving epigastric pain, dysphagia, anorexia, and weight loss.

Examination revealed an ill-looking patient with sinus tachycardia and clinical volume depletion. Epigastric palpation reproduced her pain and triggered vomiting. An incidental note was made of a diffusely enlarged, nontender thyroid, with no lymphadenopathy.

Initial blood work redemonstrated the patient's long-standing mild thrombocytopenia (80 × 109 cells/L). She had elevation of alanine transaminase (160 U/L) and aspartate transaminase (109 U/L). Liver function tests, lipase, troponin, and creatine kinase were within normal limits. An abdominal CT scan revealed no obstruction, colitis, perforation, or nephrolithiasis. Subsequent investigation revealed an undetectable thyroid-stimulating hormone (<0.02 mIU/L; normal, 0.5-5) with concomitantly elevated free T3 (14.2 pmol/L; normal, 3.1-6.8) and free T4 (78 pmol/L; normal, 10-22). She was not taking biotin supplements.

A diagnosis of hyperthyroidism was made. After initiation of propranolol 10 mg by mouth 3 times a day, she had rapid symptomatic resolution. She was able to tolerate oral intake after 1 day and was discharged home after 3 days. An outpatient 24-hour radioactive iodine thyroid uptake scan demonstrated diffusely elevated uptake at 45.2% (normal, 8%-25%).

Further identification of elevated serum thyrotropin receptor antibodies confirmed the diagnosis of Graves’ disease. She was asymptomatic and euthyroid after 4 months of treatment with methimazole, and her alanine transaminase and aspartate transaminase had also returned to within normal limits.

Case learnings:-
• Nausea and vomiting are underappreciated symptoms of hyperthyroidism.

• This case highlights the importance of conducting a thorough physical examination when the underlying etiology for gastrointestinal symptoms is not otherwise evident.

• Detection of a goiter or other signs suggestive of thyrotoxicosis, such as tremor, hyperreflexia, or ophthalmologic signs, are important clinical findings that can lead to the correct diagnosis of unexplained gastrointestinal syndromes.

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