A key cellular mechanism that shows saturated fat can worsen
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Through experiments on laboratory-cultured mouse cells and on mice fed with a diet rich in saturated fat, the NTU Singapore scientists found that saturated fatty acids can degrade a protein called FIT2, triggering a chain of molecular events that cause insulin-producing cells to lose their function and die.

The potential of increasing FIT2 production in the body as a new method to manage diet-induced diabetes. Also called Type-2 diabetes, the metabolic condition accounts for 95 percent of diabetes cases, affecting about 462 million people globally.

The scientists said that the study also reinforces, for diabetic patients, the importance of moderating their meat and dairy consumption, in addition to sugar and carbohydrates, since saturated fat is found in high amounts in red meats, processed meats, and dairy products. This study explains how saturated fats may interfere with our pancreas' ability to maintain healthy blood glucose, thereby causing or worsening diabetes.

Source: https://medicalxpress.com/news/2022-04-scientists-uncover-key-cellular-mechanism.html