A new machine learning-based approach to drug repurposing
Drug repurposing is a method of developing new therapeutic use(s) for existing drugs, for which safety and pharmacokinetics have already been demonstrated in humans. This can significantly reduce the time, cost, uncertainty, and side effects associated with drug development. First, diseases are clustered by gene expression, with the thought that similar patterns of altered gene expression imply critical pathways shared in different disease conditions. Second, drug efficacy is determined based on the ability to reverse altered gene expression, and the results are clustered to identify repurposing targets. The investigators applied their approach and identified disease-specific gene expression and 20 drugs for repurposing.

Source: https://www.liebertpub.com/doi/10.1089/omi.2022.0026