A new technology offers treatment for HIV infection through
The study with a one time injection, was developed for the first time in Dr. Barzel's laboratory. The technique developed in his lab utilizes type B white blood cells that would be genetically engineered inside the patient's body to secrete neutralizing antibodies against the HIV virus that causes the disease. B cells are a type of white blood cells responsible for generating antibodies against viruses, bacteria and more. B cells are formed in bone marrow. When they mature, B cells move into the blood and lymphatic system and from there to the different body parts.

The genetic editing was done with a CRISPR. This is a technology based on a bacterial immune system against viruses. The bacteria use the CRISPR systems as a sort of molecular "search engine" to locate viral sequences and cut them in order to disable them. Two biochemists who had figured out the sophisticated defense mechanism, Emmanuelle Charpentier and Jennifer Doudna, were able to reroute for the cleavage of any DNA of choice. The technology has since been used to either disable unwanted genes or repair and insert desired genes.

Source: https://www.nature.com/articles/s41587-022-01328-9
Like
Comment
Share