A preoperative prognostic nutritional index is a prognostic
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This study suggests that the prognostic nutritional index (PNI) offers great prognostic value in oral squamous cell carcinoma patients undergoing radical surgery.

The purpose of this study was to investigate the prognostic value of the prognostic nutritional index (PNI) in oral squamous cell carcinoma (OSCC) patients and to undertake a comparative evaluation of the prognostic value of comparing PNI, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in terms of prognostic utility.

A retrospective study was conducted involving 203 consecutive patients with OSCC who were treated with radical surgery with curative intent. The PNI and systemic inflammatory response were developed, and their prognostic utility was evaluated.

Kaplan–Meier curve analysis and log-rank testing showed that PNI, NLR, PLR, and LMR were significantly associated with overall survival. Multivariate analysis identified PNI as an independent prognostic factor for OSCC patients. In time-dependent receiver operating characteristic curve analysis, PNI was continuously superior to that of NLR, PLR, and LMR.

Conclusively, this study suggested that PNI offered an independent prognostic biomarker in OSCC patients undergoing radical surgery.

International Journal of Oral and Maxillofacial Surgery
Source: https://doi.org/10.1016/j.ijom.2021.01.009
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