A rare case of Orbital metastasis from a gastrointestinal st
Gastrointestinal stromal tumor (GIST) is the most common primary mesenchymal tumor. The most common metastasis sites are the liver and the surface of the peritoneum. This is a case of orbital GIST metastasis.

A 43-year-old woman who had a history of small intestinal stromal tumor 4 years ago suffered GIST metastasis to the left orbit. MRI confirmed the presence of a lacrimal gland lesion with isointense on T1 and hyperintense on T2 weighted images.

Histopathology analysis of the tumor showed predominantly spindle or oval cells with nuclear pleomorphism and increased mitoses. The tumor also stained positive for c-KIT (CD117) upon immunochemistry, confirming the diagnosis.

Orbital metastasis of the primary tumor occurs more in breast, lung, liver and prostate cancers. However, orbital metastasis derived from GIST is rare.

Source: American journal of ophthalmology case reports

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