A rare case of neonatal cholestasis : JCN March issue 2017
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Introduction :
Cholestatic jaundice affects approximately 1 in every 2500 infants and has a multitude of causes.[1] The number of unique disorders presenting with cholestasis in the neonatal period may be greater than at any other time in life and includes infections, anatomic abnormalities of the biliary system, endocrinopathies, genetic disorders, metabolic abnormalities, toxin and drug exposures, vascular abnormalities, neoplastic processes, and other miscellaneous causes.[2] Of the many conditions that cause neonatal cholestasis, the most commonly identifiable are biliary atresia (25%–35%), genetic disorders (25%), metabolic diseases (20%), and a1-antitrypsin (A1AT) deficiency (10%).[3] Rarely, severe liver failure of prenatal origin can present as severe cholestasis in the 1st week of life......

http://www.jcnonweb.com/article.asp?issn=2249-4847;year=2017;volume=6;issue=1;spage=34;epage=36;aulast=Ghoshal
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