A rare case of recurrent postpartum pemphigoid gestation wit
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis, specific to pregnancy, which is clinically and pathogenetically similar to bullous pemphigoid, and occurs in approximately 1 in 50000 pregnancies.

A 26-year-old female with obstetric code P5L2 (Para 5, Live 2), presented with fluid-filled lesions all over the body for more than a week. She had delivered a live baby boy of low birth weight (1.5 kgs) 15 days back. A 4-year-old girl child born out of her third pregnancy was alive. Her birth weight was 2.6 kgs and the patient did not notice any skin lesions during that period. Other three previous pregnancies ended up in still births at around 7 months of gestation which were not attributable to any other particular cause.

On examination, multiple well- to ill-defined urticarial plaques and fluid-filled blisters of 0.4 to 5 cm were seen over abdomen, chest, back, thighs, forearms, scalp, face, and hands. Bulla spread sign was positive with rounded spread. Sheklakov sign was positive and there was no mucosal involvement. Tzanck smear showed predominantly eosinophils with few neutrophils. Histopathology showed subepidermal bulla with eosinophils. Direct immunofluorescence showed a strong linear band of C3 along dermoepidermal junction. IgG was negative and the patient was started on oral prednisolone 40 mg with supportive measures. The lesions stopped appearing after 3 days. Prednisolone was gradually tapered and stopped after 4 weeks.

PG is a rare immunobullous disease against BP180 in basement membranes of skin and amniotic epithelium of placental tissues, presents with intense itchy erythematous plaques and blisters. The possibility of recurrence in subsequent pregnancy is almost 90% and usually occurs earlier and more severe. Studies have shown that PG may skip some pregnancies in 5% of patients.

In this patient, other causes of miscarriages like maternal smoking, diabetes, TORCH infection, and cholestasis were ruled out. Placental insufficiency due to preeclampsia could be the probable cause of stillbirths. Occurrence of PG in postpartum period is rare and its recurrence again in postpartum period is much rarer.

Source: https://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=6;spage=995;epage=996;aulast=Puri