A rare case report of polyangiitis overlap syndrome
Polyangiitis overlap syndrome is defined as systemic vasculitis that does not fit precisely into a single category of classical vasculitis classification and/or overlaps with more than one category. There are very few case reports of an overlap syndrome involving both Granulomatosis with polyangiitis (GPA) and Eosinophilic granulomatosis with polyangiitis (EGPA) in the medical literature. This case appears in the journal BMC Pulmonary Medicine.

A 50-year-old woman presented with an episode of hemoptysis. She also reported low grade fevers, night sweats and chest discomfort. Her past medical history was notable for allergic rhinitis/sinusitis and asthma, and she experienced recurring upper respiratory tract infections, sinusitis, and bronchitis approximately three times per year.

Chest CT imaging revealed left upper lobe consolidation with a central cavitary lesion, adjacent scattered consolidation, ground-glass opacities and tree-in-bud markings. She subsequently underwent bronchoscopy, and bronchoalveolar lavage grew Mycobacterium avium complex (MAC).

Consequently, she underwent cavitary MAC treatment with rifampin, ethambutol, erythromycin, and intravenous amikacin with improvements in low-grade fever, night sweats, and chest discomfort.

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