A rare life threatening complication of dapsone therapy - J
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Dapsone is useful for treating a variety of infectious, immunological and hypersensitivity disorders. Commonly encountered adverse effects of this drug include dose unrelated (idiosyncratic) skin hypersensitivity reactions and dose-related hemolytic anemia and methemoglobinemia. Other notable adverse effects include insomnia and psychosis. A rare, potentially fatal idiosyncratic systemic hypersensitivity syndrome- namely dapsone hypersensitivity syndrome (DHS), characterized by fever, skin rash, eosinophilia, lymphadenopathy, hepatic, pulmonary and other systemic manifestations can complicate dapsone therapy. DHS can cause irreversible organ damage or even death if not recognized early and managed properly. This article reports a case of severe, life threatening DHS with multi-organ dysfunction in a 17-year-old male, which was managed successfully with oral steroids. A brief review of DHS is also presented...

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