ANS
Balkrishna Sapariya
ANS
What is the effect of norepinephrine on normal human heart and transplanted human heart? mechanism?
K●●●●l M●●●●r and 3 others like this1 share
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B●●●●●●●●a S●●●●●●a
B●●●●●●●●a S●●●●●●a General Medicine
Mainly what is the effect on heart rate?
Dec 3, 2016Like
R●●●●a A●●●●●●r
R●●●●a A●●●●●●r General Medicine
Heart rate would increase in a normal human heart, but since a transplanted heart is denervated, there wouldn't be a way for endogenous NE to act as it is released from nerve terminals. If NE is given parenterally, it will increase the HR. Correct me if I am wrong, because even I'm not 100\% sure.
Dec 3, 2016Like
B●●●●●●●●a S●●●●●●a
B●●●●●●●●a S●●●●●●a General Medicine
When we give NA parenterally, it increase HR through beta 1 receptor but baroreceptor reflex mechanism(M3 receptor) is also there in normal human heart so it will decrease HR by vagus that is intact in normal human heart. so net effect is decreased HR... but in the case of transplanted heart... heart is not innervated by vagus so no connection to CNS... SO baro receptor reflex doesn't work... so net effect of NA is increased HR...????... Read more
Dec 3, 2016Like