Abnormal Interhemispheric functional connectivity in patient
Strabismus amblyopia can result in markedly brain function alterations. The current study intended to employ the voxel-mirrored homotopic connectivity (VMHC) method to investigate the intrinsic brain activity changes in SA patients.

This Study investigated the changes in cerebral hemispheric functional connections in patients with SA and their relationship with clinical manifestations using the VMHC method.

A total of 17 patients with SA and 17 age- and weight-matched healthy control (HC) groups were enrolled. Based on the VMHC method, all subjects were examined by functional MRI. The functional interaction between cerebral hemispheres was directly evaluated. The Pearson’s correlation test was used to analyze the clinical features of patients with SA. In addition, their mean VMHC signal values and the receiver operating characteristic curve were used to distinguish patients with SA and HC groups.

Results:
--Compared with HC group, patients with SA had higher VMHC values in bilateral cingulum ant, caudate, hippocampus, and cerebellum crus 1.

--Moreover, the VMHC values of some regions were positively correlated with some clinical manifestations.

--In addition, receiver operating characteristic curves presented higher diagnostic value in these areas.

Finally, in SA patients an aberrant interhemispheric brain connection was demonstrated in visual pathways and this could provide some informative information to comprehend SA patient's neurological mechanisms.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-02015-0
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