Absolute appendicular lean mass best predictor of osteoporos
Absolute appendicular lean mass appears to be a suitable marker for predicting osteoporosis based on low muscle mass for postmenopausal women, according to findings published in Menopause.

In a cross-sectional study, Miranda and colleagues analyzed data from postmenopausal women classified for presence of osteoporosis at the femoral neck and lumbar spine and three cutoff points for low muscle mass: appendicular lean mass of less than 15 kg; appendicular lean mass/height2 (appendicular lean mass index) of less than 5.67 kg/m2; and ratio between appendicular lean mass and BMI of less than 0.512.

After adjustments for confounding factors, binary logistic regression showed that appendicular lean mass and appendicular lean mass index were associated with osteoporosis at the lumbar spine, with ORs of 5.3 and 2.5, respectively. Only appendicular lean mass was associated with osteoporosis at the femoral neck, with an OR of 16.1.

When women were classified as having osteoporosis in at least one site, only appendicular lean mass was associated with osteoporosis, with an OR of 7.7.

There was no association between appendicular lean mass to BMI ratio and osteoporosis. The predictive value of appendicular lean mass for osteoporosis decreased after BMI or height was included as a covariate in the model.

“The predictive value for osteoporosis based on appendicular lean mass is reduced by adjustment for BMI and height measures,” the researchers wrote. “Thus, the use of absolute appendicular lean mass (less than 15 kg) seems to be the most suitable for predicting osteoporosis based on low muscle mass in postmenopausal women.”

Source: https://journals.lww.com/menopausejournal/Abstract/9000/Different_cutoff_points_to_diagnose_low_muscle.96934.aspx
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