Accurate diagnosis in suspected Acute Invasive Fungal Rhinos
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Invasive fungal rhinosinusitis (AIFRS) is a serious infection beginning in the sinuses after certain types of fungus are inhaled. This research states that positive galactomannan and MRI changes help determine the condition in suspected cases.

The aim of this study by Clinical Otolaryngology was to describe a group of patients with suspected acute invasive fungal rhinosinusitis (AIFRS) diagnosis and identify factors associated with a greater risk of presenting this disease.

A non?concurrent cohort study follow?up of patients with suspected AIFRS was carried out. 50 inpatients referred due to suspected AIFRS based on the association of a predisposing factor (neutropenia/immunodeficiency/poorly controlled diabetes) with the fever of unknown origin were included.

AIFRS was confirmed in 18% of the evaluated patients.

--AIFRS was significantly associated with a positive galactomannan and a paranasal sinus MRI with a lack of contrast enhancement (LoCE) orbit compromise or global extrasinusal extension.

--LoCE and extrasinusal extension in the paranasal sinus/brain MRI were risk factors for AIFRS.

--Conversely, a nasal endoscopy showing healthy mucosa was identified as a protective factor for AIFRS.

In particular, laboratory and radiologic variables were identified which are associated with the disease and may help for a more accurate diagnostic algorithm and approach in patients with suspected AIFRS.

Source: https://doi.org/10.1111/coa.13734
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