Acute CMV disrupts established transplantation tolerance: St
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Acute Cytomegalovirus infection leads to disruption of transplantation tolerance and subsequent recipient allo-sensitization, finds this study published by the American Journal of Transplantation.

Researchers have previously shown that acute CMV infection disrupts the induction of transplantation tolerance. This study was conducted to evaluate its impact on the maintenance of established tolerance and on subsequent recipient allo-sensitization.

Investigators used an allogeneic murine islet transplantation tolerance model. They demonstrated that;

--Acute CMV infection abrogated transplantation tolerance during the maintenance stage in 50%-60% of recipients.

--Acute CMV infection–mediated tolerance disruption led to recipient allo-sensitization by reverting the tolerant state of allo-specific T cells and promoting their differentiation to allo-specific memory cells.

--Consequently, a second same-donor islet allograft was rejected in an accelerated fashion by these recipients.

The study supports close monitoring for allo-sensitization in previously tolerant transplant recipients in whom tolerance maintenance is disrupted by an episode of acute CMV infection.

Source: https://doi.org/10.1111/ajt.16197
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