Acute Hypotensive Blood Transfusion Reaction: Intraop Dx and
Acute hypotensive transfusion reaction (AHTR) is characterized by the abrupt onset of hypotension immediately after the start of transfusion and usually resolves when transfusion ceases. Recent studies have shown an association with pre-operative treatment with an ACE inhibitor. This report, published in the American Journal of Case Reports presents two cases of AHTR and describes the diagnosis and management.

A 68-year-old woman underwent lumbar fusion surgery due to spinal stenosis and an 86-year-old man underwent a pancreaticoduodenectomy (Whipple’s procedure). Both patients had been treated pre-operatively with ACE inhibitors for hypertension.

During surgery, both patients experienced acute profound intraoperative hypotension immediately after transfusion of packed red blood cells (RBCs). The blood transfusion was stopped immediately, and hemodynamic support was given with epinephrine, ephedrine, and phenylephrine. A diagnosis of acute hemolytic transfusion reaction was excluded by the direct antiglobulin test, serum hemolysis testing, exclusion of blood group mismatching, and a post-transfusion antibody screen.

Other causes of hypotension were excluded. The two patients were confirmed t have had an AHTR, based on the current Centers for Disease Control and Prevention (CDC) criteria. In both cases, discontinuation of surgery was not possible, and surgery continued with intermittent hemodynamic support provided with catecholamines and vasopressin.

Learning Points:-
- AHTR is a diagnosis of exclusion, based on laboratory and clinical findings.

- Antibody-mediated acute hemolytic transfusion reaction and any other causes of hypotension should be excluded as rapidly as possible.

- Patients who are at high risk of intraoperative bleeding might benefit from cessation of ACE inhibitors pre-operatively.

Read in detail here:
Dr. K●●●l R●●a and 2 other likes this1 share
Dr. Z●●s D●●●●●a
Dr. Z●●s D●●●●●a Internal Medicine
In hemolytic reaction remember, blood oozes out of the surgical sites...that usually doesn' t happen in hypotensive reaction...
Nov 29, 2018Like