Acutely ill Psychatric in patients and antimicrobial exposur
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Patients with schizophrenia, bipolar disorder, and major depressive disorder (MDD) have increased infections. Researchers explored the association between recent antimicrobial exposure and acute psychiatric illness.

A retrospective chart review of 267 acutely ill patients age 18 to 65 was performed. There were 92 patients with schizophrenia, 42 with bipolar disorder, 61 with MDD, and 72 with alcohol use disorders (hospitalized controls). Recent antimicrobial exposure was defined as occurring within 3 days of psychiatric hospitalization.

The prevalence of recent antimicrobial exposure was significantly increased in acutely ill patients with schizophrenia (16%), bipolar disorder (21%), and MDD (18%) compared with patients who had alcohol use disorders (4%). After controlling for potential confounders, participants with schizophrenia or mood disorders were 5 to 7 times more likely to have recent antimicrobial exposure than participants with alcohol use disorders (schizophrenia: odds ratio OR = 4.5, bipolar disorder: OR = 6.9, MDD: OR = 5.7). Among participants with mood disorders, the association was stronger for participants with depression and affective psychosis compared with participants with alcohol use disorders.

They found an increased prevalence of recent antimicrobial exposure in acutely ill patients with schizophrenia and mood disorders. The findings provide additional evidence that infections are relevant to acute psychiatric illness.

Source: https://www.aacp.com/article/buy_now/?id=661
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