Adding levosimendan to epinephrine improves initial resuscit
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Abstract
Background

Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-induced cardiac arrest in rats.

Methods

Animals underwent asphyxial cardiac arrest/cardiopulmonary resuscitation, randomized to three treatment groups: epinephrine (10 ?g/kg) supplemented with levosimendan (bolus 12 ?g/kg and infusion for 1 h, EL group); epinephrine only (10 ?g/kg, E group), or levosimendan only (bolus 12 ?g/kg and infusion for 1 h, L group). The resuscitation success rate, wet-to-dry ratio of lung, and rate of alveolar and blood gas analysis were recorded.....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289016/
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