Adherence to asthma biologic therapy higher than inhaled cor
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In a new study, adherence to asthma biologic therapy was higher than adherence to inhaled corticosteroids among adults with asthma.

Little is known about adherence to asthma biologics. This study aimed to find if adherence to inhaled corticosteroid (ICS) associated with subsequent asthma biologic adherence.

Researchers analyzed individuals with asthma who started asthma biologics in the OptumLab Data Warehouse and used that data until October 2019. They calculated proportion days covered (PDC) for ICS ± long-acting β-agonists in the 6 months before and after asthma biologics were started and asthma biologic PDC for the first 6 months of use. They performed a multivariable analysis to identify factors associated with asthma biologic PDC more than 0.75, ICS PDC more than 0.75 during the 6-month period after asthma biologic were started, and achievement of a greater than 50% reduction in asthma exacerbations during the first 6 months of asthma biologic use.

Results:
-- Researchers identified 5,319 people who started asthma biologics.

-- The mean PDC for asthma biologics was 0.76 in the first 6 months after starting, higher than the mean PDCs for ICS in the 6 months before (0.44) and after (0.40) starting the asthma biologic.

-- PDC greater than 0.75 for ICS 6 months before index biologic use is associated with PDC for asthma biologics greater than 0.75 and for ICS during the first 6 months of biologic use.

-- Neither ICS PDC greater than 0.75 nor asthma biologic PDC greater than 0.75 is associated with a statistically significant reduction in asthma exacerbations during the first 6 months of asthma biologic use among people with any exacerbation in the 6 months before first use.

Conclusively, adherence to asthma biologic is higher than to ICS and is associated with different factors.

Source: https://journal.chestnet.org/article/S0012-3692(20)35101-1/fulltext
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