Admission Serum Chloride Levels Prognostic Markers For Heart
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Recent studies have shown that lower serum chloride is associated with diuretic resistance and increased mortality in heart failure. Impact of lower admission chloride on duration of stay in acute decompensated heart failure (ADHF) has not been studied previously.

In this retrospective analysis, researchers studied the effect of admission serum chloride on the duration of hospital stay in patients admitted with ADHF. A total of 167 patients were studied. Serum chloride levels were divided into tertiles - less than96 meq/L (tertile 1), 96–101 meq/L (tertile 2), and greater than 101 meq/L (tertile 3) based on the distribution of serum chloride levels in our patients.

Results:
-- The median lengths of hospital stay in tertiles 1, 2, and 3 were 8, 7, and 6 days, respectively.

-- Admission serum chloride levels were inversely associated with duration of stay.

-- On multiple linear regression analysis, serum chloride remained independent predictor of increased hospital stay while association with serum sodium was not significant.

-- 1 unit increase in chloride level was associated with 1.3% decrease in hospital stay.

Conclusively, This retrospective analysis suggests that admission serum chloride levels are independently and inversely associated with increased duration of stay. This is independent of admission sodium levels. Thus serum chloride, rather than sodium, is an important poor prognostic marker in heart failure patients.

Source: https://www.japi.org/x26484c4/admission-serum-chloride-levels-as-predictor-of-stay-duration-in-acute-decompensated-heart-failure
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