Adolescents with depression at increased risk for thyroid di
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Assessment of thyroid function may be warranted among adolescents with depression because of their increased risk for subclinical hypothyroidism and thyroid autoimmunity, according to a study published in Journal of Clinical Psychiatry.

The study was undertaken to determine the prevalence of subclinical and overt thyroid dysfunction as well as thyroid autoimmunity in depressed adolescents in comparison to the general pediatric population. Additionally, the relationship between parameters of thyroid function and Beck Depression Inventory-II (BDI-II) scores was examined.

Parameters of thyroid function (thyrotropin, free thyroxine, thyroid peroxidase antibodies) and prevalence of thyroid dysfunction and autoimmunity were determined in 360 adolescents (11–19 years) with at least mild depression (BDI-II score more than 13) and in a representative reference cohort without evidence of impaired mental health from a nationwide survey (German Health Interview and Examination Survey for Children and Adolescents [KiGGS]).

Results:
-- There was a higher prevalence of thyroid peroxidase antibody positivity in depressed adolescents compared to KiGGS participants.

-- The prevalence of subclinical hypothyroidism was likewise higher in depressed adolescents, but no other types of thyroid dysfunction had a higher prevalence.

-- There was no significant relationship between parameters of thyroid function and BDI-II scores, as examined by multiple regression considering relevant covariates.

-- The positive results were verified in a subsample of patients with a confirmed diagnosis of depression (N=284).

Conclusively, the prevalence of subclinical hypothyroidism and of thyroid autoimmunity in depressed adolescents is increased. The etiology of these observations is not well understood, and further studies to examine the underlying relationship are required. Moreover, thyroid autoimmunity may constitute an additional risk factor for depression on its own.

Source: https://www.psychiatrist.com/jcp/depression/increased-prevalence-of-subclinical-hypothyroidism-and-thyroid-autoimmunity-in-depressed-adolescents-results-from-a-clinical-cross-sectional-study-in-comparison-to-the-general-pediatric-population/
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