Adults with acromegaly have more comorbidities, prescribed m
Acromegaly is a rare disease with a significant delayed diagnosis, up to 10 to 11 years; thus, at diagnosis, patients already have many complications. In a large study, which included patients with acromegaly with active disease on medical therapy, hypopituitarism and hypothalamic disorders, sleep apnea, malignant neoplasms, arthritis as well as musculoskeletal disorders had high prevalence in the acromegaly cohort compared with the general population as expected.

The acromegaly cohort had a higher prevalence of cardiovascular disease (67.6% vs. 48.4%), hypopituitarism and disorders of hypothalamus (26.3% vs. 0.2%), sleep apnea (24.9% vs. 7.8%), malignant neoplasms and cancer (22.6% vs. 8.6%), and arthritis and musculoskeletal disorders (19.9% vs. 12.9%) compared with the control cohort. Those with acromegaly were also prescribed more antibacterials for systemic use (70% vs. 55.6%), analgesics (56.3% vs. 38.1%), cough and cold preparations (46.4% vs. 35.5%), psycholeptics (42.6% vs. 24.8%) and sex hormones and modulators of the genital system (37.3% vs. 12.7%) compared with controls.

Source: https://www.healio.com/news/endocrinology/20220401/adults-with-acromegaly-have-more-comorbidities-prescribed-more-concomitant-medications
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