Adults with inflammatory bowel disease are at a greater risk
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Both inflammatory bowel disease (IBD) and chronic rhinosinusitis (CRS) are characterized by dysregulated immune responses. IBD and the subsequent risk of CRS in a nationwide setting was examined.

A total of 8,313 patients over the age of 20 years with IBD were included. Researchers randomly extracted 33,252 cases without IBD to create a comparison group matching patients by age, sex, and index year. Cumulative incidences were obtained using the Kaplan–Meier method, & we calculated risk estimates for the development of CRS using the Cox proportional hazards model.

In 295,007 person-years, researchers identified 521 (1.25%) cases of IBD. The IBD cohort had a 1.26 fold (95% confidence interval [CI], 1.17–1.35) greater risk of developing CRS than the comparison group; for ulcerative colitis it was 1.73 fold (95% CI, 1.48-2.05) and for Crohn's disease was 1.20 fold (95% CI, 1.11-1.29). Subsequent analysis stratified by age revealed that the risk was highest among the population with IBD aged 50 to 64 years (adjusted hazard ratio - 1.37; 95% CI, 1.18-1.59). A follow up specific analysis demonstrated that the risk appeared to be highest with a follow up duration of less than 2 years.

The present analysis indicates that personal history of IBD, especially the phenotype ulcerative colitis, is associated with increased risk of subsequent CRS.

source: https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13647
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