All-cause and Cancer-specific death of Older adults followin
This JAMA study shows that for older adults selected for cancer surgery, the relative burden of cancer deaths exceeds death from other causes, even in more vulnerable patients.

The objective of this study was to examine all-cause and cancer-specific death throughout 5 years for older adults after cancer resection.

This population-based cohort study was conducted in Canada, using the administrative databases stored at ICES. All adults 70 years or older who underwent resection for a new diagnosis of cancer between January 1, 2007, and December 31, 2017, were included. Patients were followed up until death or censored at the date of the last contact of December 31, 2018.

- Of 82 037 older adults who underwent surgery, 16 900 of 34 044 deaths were cancer-related at a median follow-up of 46 months.

- At 5 years, the estimated cumulative incidence of cancer death exceeded noncancer death among all patients.

- However, noncancer deaths exceeded cancer deaths starting at 3 years after surgery in breast, prostate, and melanoma skin cancers, patients older than 85 years, and those with frailty.

- Cancer type, advancing age, and frailty were independently associated with cause-specific death.

Conclusively, at the population level, the relative burden of cancer deaths exceeds noncancer deaths for older adults selected for surgery.

JAMA Surgery