Alterations of brain metrics in fetuses of women with polycy
Maternal polycystic ovary syndrome (PCOS) has potentially detrimental effects on the neurodevelopment of offspring. This study aimed to evaluate the brain metrics in fetuses of women with PCOS based on fetal magnetic resonance imaging (MRI).

This retrospective study included 60 pregnant women with PCOS (PCOS group) and 120 pregnant non-PCOS women (control group). Fetal MRI was performed followed by an ultrasound and for numerous clinical indications including known or suspected fetal pathology, history of fetal abnormality in a previous pregnancy or in a family member.

After adjusting for potential confounders, fetuses in the PCOS group showed the following characteristics compared to fetuses in the control group:

(1) smaller cerebral fronto-occipital diameter (FOD), vermian height (VH), and anteroposterior diameter of the pons (APDP);

(2) larger left and right biparietal index;

(3) smaller left lateral ventricle (LV);

(4) larger anteroposterior diameter of the vermis (APDV) and hippocampal infolding angle (HIA);

(5) higher ADC value in frontal white matter (FWM) and in basal ganglia (BG).

In conclusion, there exists a different pattern of brain metrics in PCOS offspring in utero.

BMC Pregnancy and Childbirth