Altered thiol/disulfide homeostasis and ischemia-modified al
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In this study, Researchers assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children that inferred that increased levels can be etiological factors.

56 children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS.

Results:
--The mean values of native thiol, total thiol, and disulfide were 343.779 ± 138.654 mol/L, 365.398 ± 140.148 mol/L, and 23.190 ± 4.978 mol/L, respectively, in the IBS group and 409.908 ± 69.288 mol/L, 433.481 ± 76.891 mol/L, and 20.090 ± 4.252 mol/L, respectively, in the control group.

--Native thiol and total thiol values were significantly reduced in the IBS group compared with the control group.

--The mean IMA values were 0.835 ± 0.083 (g/L) and 0.778 ± 0.072 in the IBS and control groups, respectively. The IMA value was significantly increased in the IBS group.

Conclusively, Impaired thiol/disulfide homeostasis and increased IMA levels can be considered etiological factors in children with IBS.

Source: https://onlinelibrary.wiley.com/doi/10.1111/ped.14406?af=R
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