Alzheimer And Covid 19 Share Common Genetic Risk Link
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In a new research, scientists have identified a gene that impacts the risk of both Alzheimer’s disease and severe COVID-19. They sequenced genetic data from 2,547 people, half of whom had Alzheimer’s disease. They found that one genetic variant of the OAS1gene increases the risk of Alzheimer’s disease by about 3-6 per cent in the population while related variants on the same gene increase the likelihood of severe COVID-19 outcomes. This newly identified gene is expressed in microglia, a type of immune cell that constitutes around 10% of all cells found within the brain and can contribute to an exaggerated immune response to increase risks of both Alzheimer’s and COVID-19. Findings also revealed that the variants increasing the risk of Alzheimer’s disease are inherited together with OAS1 variants recently found to increase the risk of needing intensive care for COVID-19 by as much as 20%.

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https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab337/6382473?searchresult=1
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