Am I allergic to Penicillin?
Penicillin is one of the most commonly used antibiotics. Penicillin antibiotics are a large group of chemically related drugs that can be given by mouth or injection to treat many bacterial infections and are part of the group of drugs called beta-lactam antibiotics.

ARE PENICILLIN ALLERGIES COMMON?
About 1 in 10 patients has a penicillin allergy noted in their medical record. Many such allergies are diagnosed in childhood, often because of a rash that may have been caused by a virus, not an allergy. Even among patients with true penicillin allergy, 8 in 10 are no longer allergic within a 10-year period.

EVALUATION FOR PENICILLIN ALLERGY
- Penicillins and other beta-lactam antibiotics are some of the safest and most effective antibiotics for many infections, and therefore it is important to find out if you are really allergic to penicillin.

- Having an unverified penicillin allergy may result in other antibiotics being used to prevent and treat infections, which may result in an increased risk of the following:

• Treatment failures for some infections that are best treated with penicillin (or related beta-lactam) antibiotics

• Health care-associated bacterial infections, such as Clostridium difficile (also known as Clostridioides difficile) infection and surgical site infections

• Adverse events from other antibiotics that may have more side effects

DIAGNOSIS OF PENICILLIN ALLERGY
• Penicillin allergy can be evaluated by first obtaining a careful history related to the symptoms of the reaction. An initial skin prick test is done by pricking the skin with a small amount of each form of penicillin reagent.

• A second test is an intradermal test, given when the skin prick test is negative. This test uses a small needle to place the reagent right underneath the skin. After each test, the test area is examined after 15 to 20 minutes.

• The intradermal test may sometimes be repeated. If these tests are negative, it is unlikely that a patient is allergic to penicillin. To confirm, an oral dose of a penicillin drug is then given under clinician observation.

• If the symptoms of reaction are low risk, such as headache, nausea, vomiting, itching, or family history of allergy, skin tests may not be done before penicillin is given. In some patients, the first dose may be given under observation.

• If 1 full dose of penicillin is tolerated, there is no risk of a serious immediate reaction to a penicillin antibiotic, so penicillin can be used in future treatment. However, an allergic reaction to any drug can occur at any time, and this test does not detect all forms of allergic reactions and does not detect intolerances to or side effects of penicillin.

Source: https://jamanetwork.com/journals/jama/fullarticle/2720729
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Dr. S●●●●●v S●●●●●1
Dr. S●●●●●v S●●●●●1 Obstetrics and Gynaecology
Though Penicillin injections are extremely effective and well tolerated it' s rare to find Penicillin therapy now-a-days. Even most renowned doctors are afraid to administer Penicillin in the pretext of allergic and anaphylactic reactions. Hence injections are difficult to get in the market.
Jan 16, 2019Like6