Amiodarone: A potential risk factor for retinal phototoxicit
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The eye is more vulnerable to phototoxicity than other organs in the body as the optics of the eye are designed to concentrate and focus light on the retina. Retinal phototoxicity can occur through three mechanisms: photothermal, photomechanical and photochemical. Many pharmacologic agents have the ability to change a patient's sensitivity to solar or artificial radiation. Drugs may act as photosensitizers leading to photochemical damage. Photosensitizing drugs deposit in the retina and when activated by light, release reactive oxygen species that cause oxidative damage to various cellular components. We present here the only known case, to our knowledge, of retinal phototoxicity as a result of photosensitization from systemic amiodarone use

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