Amyloidoma secondary to insulin injection
The present case has been reported in the British Journal of Dermatology.

A 34‐year‐old woman with a history of insulin‐dependent diabetes mellitus presented with an 8‐cm subcutaneous abdominal mass. The mass was resected and gross examination showed an ill‐defined yellow firm cut surface.

Histological examination showed extensive deposition of amorphous homogeneous eosinophilic extracellular material with prominent chronic inflammation and foreign body giant cell reaction (b). Congo red stain showed pink amyloid deposits (c) and under polarized light, the Congo‐red‐stained amyloid showed green birefringence (d).

Liquid chromatography-tandem mass spectrometry performed on peptides extracted from Congo‐red positive areas of the paraffin-embedded specimen detected a peptide profile consistent with Alns (insulin)‐type amyloid deposition.

Alns amyloidosis is an iatrogenic form of amyloidosis localized to insulin injection sites in patients with diabetes and is not associated with systemic amyloidosis.

Source: https://pxmd.co/BPCw5
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