An Alternative Substrate to Visualize Active Viral Assemblie
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Macromolecules orchestrate processes to maintain cells and tissues, having a critical role in biomedical research. Transmission electron microscopes (TEM) are used to illuminate the structural complexities of biological assemblies for interpreting molecular mechanisms. The use of innovative new materials in the electron microscopy (EM) field may advance current practices to view biological structures and to understand their related functions. Amorphous carbon is the conventional support material used to prepare biological specimens for cryo-EM structure determination. Micron-sized holes produced in carbon support films provide a transparent view through select regions in the film, creating the ideal background for imaging weak-phase objects such as biological assemblies....

http://www.avensonline.org/fulltextarticles/jamt-2474-1914-01-0001.html
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