An adolescent female with Bipolar disorder presenting with l
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This article proposes close monitoring of thyroid hormone levels in children on lithium therapy.

Bipolar disorders are common in adolescents, with a lifetime prevalence of 2.5% and 0.1% in children aged 9–13 years. Lithium is commonly used for the treatment of bipolar disorders in children and adolescents. It has been associated with several endocrine disorders including thyroid dysfunction, diabetes insipidus, and hyperparathyroidism. Its suppressive effect on thyroid function is well known; in contrast, lithium-induced hyperthyroidism is rare with a prevalence in the range of between 1% and 1.7% in the adult population.

A 17-year-5-month-old female presented with bipolar disorder who was treated with lithium. She had been placed on Concerta, Abilify, and Lamictal before being switched to lithium monotherapy due to the limited success of these initial therapies. She responded well to lithium for two years until about 3-4 weeks prior to presentation, when she developed dizziness, heat intolerance, excessive sweating, tremors, and palpitations. Due to these symptoms, she stopped taking lithium and sought medical attention at her primary care provider's (PCP's) office. The PCP ordered laboratory tests which revealed a `suppressed TSH (<0.02 mcIU/mL, normal range: 0.35–5.50) and an elevated free T4 (3.5 ng/dL, normal range: 0.8–1.9), both consistent with hyperthyroidism.

Since thyroid autoantibodies were negative, thyroid dysfunction was attributed to lithium toxicity. Indeed, her clinical and biochemical hyperthyroid state resolved after stopping lithium therapy. Lithium-associated hyperthyroidism can occur in the pediatric population. We propose close monitoring of thyroid hormone levels in children on lithium therapy.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037979/
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