An overwhelming post-splenectomy infection (OPSI)
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We present the case of a 25 year-old man who had a splenectomy five years previously following a road traffic accident (RTA). He presented to our A&E department one evening with fever and upper abdominal pain associated with nausea & vomiting. Clinical examination was unremarkable. Initial investigations revealed only pyuria. He was treated symptomatically along with parenteral antibiotic and admitted to the general medical ward. Within few hours he deteriorated rapidly with septic shock, multi-organ failure, disseminated intravascular coagulation (DIC) and eventually cardio-respiratory arrest. Despite all resuscitative measures he died within few hours of admission...

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