Anaesthetic Mx for parturients with severe cystic fibrosis:
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Cystic fibrosis (CF) affects 1:1600 to 1:2500 live births and results from mutations of the CF transmembrane conductance regulator protein on the long arm of chromosome 7. It is inherited in an autosomal recessive manner with a gene frequency of 1:22. Despite impaired longevity, the fertility of female CF sufferers is unaffected, and many have completed successful pregnancies.

Although guidance for anaesthesia in this patient group is available, management and outcome data associated with more severe cases are sparse.

Published in the International Journal of Obstetric Anesthesia, the authors present a series of four CF patients with unplanned pregnancies who had very poor respiratory function, FEV1 <40% of predicted, and who all suffered regular infective exacerbations. Pre-pregnancy counselling, which should be given where possible to all CF females of childbearing age, was not possible.

The patients were committed to their pregnancies, declined termination and were delivered by elective caesarean section. Multidisciplinary management included their CF team (CF physician, CF specialist nurse and physiotherapist), obstetric and anaesthetic review every four weeks initially.

Three of the four patients required hospitalisation from 24, 28 and 30 weeks of gestation until their delivery. The authors present the cases and discuss their anaesthetic management during delivery and in the immediate postoperative period.

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Dr. J●●●r T●●●●●●●a and 1 others like this
Dr. L●●●●●●●●u S●●h
Dr. L●●●●●●●●u S●●h Obstetrics and Gynaecology
I have come to know about such conditions, though it is rare but such acondition can also be faced and know about the management.
Nov 3, 2018Like