Analysis of Fluid Volume through artificial intelligence for
A Study was conducted to investigate the quantitative differences in fluid volumes between subretinal fluid (SRF)–tolerant and SRF-intolerant treat-and-extend regimens for neovascular age-related macular degeneration and analyze the association with best-corrected visual acuity.

Macular fluid (SRF and intraretinal fluid) was quantified on optical coherence tomography volumetric scans using a trained and validated deep learning algorithm. Fluid volumes and complete resolution was automatically assessed throughout the study. The impact of fluid location and volumes on best-corrected visual acuity was computed using mixed-effects regression models.

--Baseline fluid quantifications for 348 eyes from 348 patients were balanced.

--No quantitative differences in SRF/intraretinal fluid between the treatment arms was found at any study-specific time point.

--Compared with qualitative assessment, the proportion of eyes without SRF/intraretinal fluid did not differ between the groups at any time point.

--Intraretinal fluid in the central 1 mm and SRF in the 1-mm to 6-mm macular area were negatively associated with best-corrected visual acuity (?2.8 letters/100 nL intraretinal fluid and ?0.20 letters/100 nL SRF).

Automated quantification of fluids utilizing artificial intelligence ensures objective and accurate measurement of the volume and location of macular fluids. Precise fluid parameter determination helps to enhance the therapeutical effectiveness of treatment during macular degeneration related to the neovascular age.