Analysis of OPD-Scan and Pentacam Parameters for Early Kerat
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A Retrospective case-control study. Case group included 50 clinically unaffected fellow eyes diagnosed with asymmetric keratoconus showing subtle qualitative changes at the 0.5D sensitivity OPD-Scan scale, as well as normal anterior and back elevation difference map at Belin/Ambrósio enhanced ectasia display (BAD) at the Pentacam. Control group included 172 normal eyes who underwent Lasik surgery and presented no complications throughout the two-year follow-up period. OPD-Scan and Pentacam parameters were compared, calculating sensitivity, specificity and area under the receiver operating characteristic curve (AUC). A multivariate analysis was performed using Pentacam or OPD-Scan variables, and a model using variables of both devices.

Pentacam variables with AUC 0.8 were keratoconus index (0.85), index of height decentration (0.81) and overall deviation at BAD (0.8). OPD-Scan variables with AUC 0.8 were keratoconus prediction index (0.83), surface asymmetry index (0.83) and total of higher order trefoil aberration (0.8). In the multivariate analysis, in the case of OPD-Scan the AUC was 0.85, while in the case of Pentacam it was 0.89. When combining all variables from the two devices, the AUC was 0.93, with a sensitivity of 82% and specificity of 94%.

Several parameters of OPD-Scan and Pentacam can be useful to differentiate cases from normal control eyes, demonstrating even better results when combining parameters of both devices. Anterior corneal indexes were the most important parameters to discriminate both groups.

Read more : https://www.sciencedirect.com/science/article/abs/pii/S0002939421000325?dgcid=rss_sd_all
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