Analysis of the causes and influencing factors of fetal loss
The risk of fetal loss is higher among ≥35-year-olds than younger women. The present study aimed to explore the causes and factors influencing fetal loss in advanced maternal age (AMA).

AMA women with singleton fetuses who underwent their first prenatal examination were included in this cohort study. A baseline survey was conducted, and follow-up was carried out until the termination of the pregnancy. Clinical data were extracted to analyze the causes of fetal loss among them. In the nested case-control study, the AMA women with fetal loss were enrolled as the case group, and women without fetal loss in the same period were enrolled as the control group, in a 1:2 ratio matched by age and gestational weeks.

A total of 239 women with fetal loss and 478 controls were enrolled.

- The causes of fetal loss were most often fetal factors, followed by maternal factors, umbilical cord factors, and placental factors.

- Multivariate logistic regression analysis indicated that junior high school education and below, senior high school education, residence in a rural area, unemployment, spontaneous abortion history, preterm birth history, hypertensive disorders of pregnancy, and preterm premature rupture of membranes were risk factors for fetal loss.

In conclusion, low educational level, unemployment, abnormal pregnancy/labor history, and pregnancy complications were correlated with the incidence of fetal loss in AMA.

BMC Pregnancy and Childbirth