Androgen Receptor Inhibitors Used To Treat Prostate Cancer M
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In recent research, a group of scientists at the University of Michigan have found that androgen receptors that are used to treat prostate cancer may also be effective against COVID-19 . Androgen receptors are specific proteins present on the surface of certain cells that bind to the male hormones testosterone and dihydrotestosterone.

The team found that androgen receptors in the lungs regulate TMPRSS2. Blocking these receptors reduces the expression of both ACE2 and TMPRSS2. The researchers used anti-androgen drugs including enzalutamide, apalutamide and darolutamide for the study.

BET proteins are transcription regulators that controls growth and differentiation. They also control inflammation and play a role in androgen signalling. The researchers also studied drugs that degrade BET proteins or inhibit their function. It was found that BET inhibitors suppressed androgen signalling and prevented viral infection.

The researchers also found more androgen signalling in the lungs of men than women, which they suggested explains why men are more prone to coronavirus disease than women. Additionally, older men who smoke have the highest androgen signalling.

Source:
https://www.pnas.org/content/118/1/e2021450118
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